University admission examinations and the future are normal concerns for high school students like Shouichi Kamita. It is also at this period of life when a strange feeling that perplexes people of all ages may begin to weigh heavily on one's mind—love. Shouichi finds three girls he could see himself having a future with at this point in his adolescence: the ever-cheerful Hikari Tsuneki, who teases Shouichi mercilessly but actually has a softer side; the competitive gamer, Tooru Miyamae, who has difficulty communicating with others; and Shouichi's childhood friend, Kyouko Touno, the sometimes immature shoujo manga enthusiast. Seiren chronicles Shouichi's interactions with these three females over three distinct arcs, as their sentiments develop from mutual interest to something more lovely.